Studies / Children

 

Children: fit4future powered by DAK-Gesundheit

Background:
In Germany, 15% of children and adolescents are overweight, of whom approximately 7% are obese. This can be attributed to a lifestyle behavior nowadays. It is therefore important to establish health promotion behavior as early as possible in childhood.

Objective:
The objective of the project fit4future powered by DAK-Gesundheit is to strengthen the health behavior of children in the areas of physical activity, healthy diet and brain fitness/stress management. In addition, respective measures will be implemented in order to promote the physical health of all involved parties.

Design:
Nationwide, 2.000 primary schools are going to be recruited. The evaluation takes place on school, teacher and children level. The examinations and interviews will be done at the beginning of the project as well as at the end of each school year, over a period of three years.

Collaborations:
planero GmbH
Cleven-Stiftung Deutschland
DAK-Gesundheit

Children: LOGIC Trial Study

Long-term effects of a lifestyle intervention in Obesity and Genetic Influence in Children

Background:
The prevalence of childhood obesity has increased worldwide. Obesity is associated with many negative immediate and long-term health consequences. Therefore, effective therapy strategies are strongly recommended.

Objective:
The aim of the LOGIC trial is to investigate the determinants for short-, middle- and long-term weight-loss and weight maintenance after a controlled inpatient lifestyle intervention program in overweight and obese children and adolescents.

Design:
•    Prospective longitudinal cohort study, n = 1.500 overweight and obese children and adolescents between 6 and 19 years
•    Intervention: standardized 4 to 6 weeks inpatient weight-loss therapy which focuses on a calorie restricted balanced diet, an increase in physical activity and behavioral counseling.
•    Primary endpoint: Associations between polymorphisms in adiposity-relevant genes (e.g. FTO, MC4R, TMEM-18) on the changes in BMI and BMI-SDS after a controlled lifestyle intervention (4 to 6 weeks) in overweight and obese children and adolescents
•    Secondary endpoints are the short- (4 to 6 weeks), middle- (6 to 12 months), and long-term (2, 5 and 10 years) effects of the intervention on anthropometric parameters, lipid and glucose metabolism, adipokines and inflammatory markers as well as physical fitness, quality of life and lifestyle behavior.

Collaborations:
Dr. Langhof, Klinik Schönsicht Berchtesgaden
Prof. Wolfang Koenig, Herzzentrum München
Prof Martin Wabitsch, Department of Pediatrics and Adolescent Medicine, University of Ulm
Prof. Kurt Widhalm, Dr. Harald Widhalm, Wien
Prof. Renate Oberhoffer, Präventive Pädiatrie, München
Dr. Harald Grallert, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

Funding:
Else Kröner-Fresenius-Stiftung
Deutsche Rentenversicherung Bayern Süd

More information:
logic.sport.med.tum.de
Clinical Trials.gov: NCT01067157

Children: JuvenTUM Study

Background:
Regular physical activity during childhood is associated with lower prevalence of overweight and obesity, with improved cardiovascular fitness and cardiometabolic health. The environment at school has the great potential to promote a healthy lifestyle to children of different socio-economical and ethnic backgrounds.

Objective:
The primary aim of JuvenTUM is to increase physical activity in and outside of school and to encourage children in a healthy lifestyle. Secondary endpoints are prevention of early macro- and microvascular impairments, reduction of cardiometabolic risk factors and improvement of physical fitness.

Design:
JuvenTUM Step 1 and 2 comprised 10 health-related lessons at school over a period of one year for children in primary schools. Parents and teachers attended two and three educational health-related lessons, respectively, and also received ten newsletters on health issues. Additional, a multidisciplinary weekly program for overweight and obese children was offered in JuvenTUM Step 2.
JuvenTUM Step 3 included weekly lifestyle lessons for children in intermediate schools aiming at increasing physical activity in and outside of school as well as health behaviour and well-being over a period of four years.

Funding:
Bayerisches Staatsministerium für Gesundheit und Pflege
BMW BKK

More information:
www.juventum.med.tum.de
Clinical Trial Registration Number: NCT00988754

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